Treatment at ICPM: Hyaluronic Acid Treatments in Valencia

In short

  • A lump is not a diagnosis. It may be product, swelling, a late nodule or an infection, and only one of those four is solved by dissolving.
  • The first thing is to rule out the urgent. Increasing pain, pallor or a change of colour are not a lump: they are grounds for immediate attention.
  • Late reactions usually appear between three and four months, and have three possible causes: the product itself, an infection or biofilm, and an immune imbalance.
  • The course of action changes with the type: hyaluronidase in non-inflammatory ones with no infection, watchful waiting or a steroid in inflammatory ones, and drainage with culture and an antibiotic if there is an infection.
  • Perfect symmetry does not exist. No face is symmetrical to begin with, and some of what is perceived as a failure of the filler was there before.
  • The first week is no use for judging anything: it is when the area is at its most swollen.

Noticing a lump where there was nothing before, or seeing one side different from the other, is one of the most frequent reasons someone comes back after a filler. And the useful answer is almost never “we’ll dissolve it”, because under the same word — lump — there are at least four things that are treated differently: accumulated product, swelling from the first few days, a late nodule or an infection.

This page explains how they are told apart, what is called for in each case and at what point a lump stops being something to watch and becomes something to assess without waiting.

This page expands on a specific problem with hyaluronic acid treatments. If what you notice is not a localised lump but a filler that “has moved”, the page for you is migration or swelling.

First of all: ruling out what will not wait

Although this page is about an aesthetic problem, the order matters. A lump accompanied by pain that is getting worse, by pallor or mottling of the skin, or by any disturbance of vision, is not a problem of badly distributed filler: it is a possible vascular complication and it is seen to immediately. It is described in the page on vascular occlusion.

With that ruled out, you can think calmly.

The four things we call a “lump”

  • Accumulated product. The filler is where it was placed, but there is more of it than that area will take, or it is in too superficial a plane. It feels firm and well defined, it does not hurt and it does not change with time. It is the commonest and the simplest to resolve. In the area under the eyes, where the skin is especially thin, product that is too superficial may also leave a bluish tinge: the so-called Tyndall effect, described alongside malar oedema as one of the complications particular to filler in that region.
  • Early swelling. In the first few days the area is diffusely swollen from the injection itself. It is not a lump: it is the whole area. It settles on its own.
  • Late nodule. It appears weeks or months later, when the result had already been taken as good. It is the one that causes most alarm and calls for most judgement.
  • Infection. It is usually accompanied by redness, warmth, pain and sometimes feeling generally unwell. It is uncommon, and it is the situation in which dissolving is not the answer.

Late nodules, which raise the most questions

The consensus published in 2024 on late reactions to hyaluronic acid places them usually between three and four months after the injection, although they occasionally appear much earlier, even within the first 24 hours.

As to why they happen, that consensus identifies three hypotheses:

  1. The product itself, and in particular low molecular weight hyaluronic acid, which can trigger an immune response.
  2. An infection, introduced during the injection or through the activation of a latent biofilm.
  3. An imbalance in the patient’s immune system, from an autoimmune disease or a viral infection, which prolongs the foreign body reaction.

This explains something that is very puzzling: that a nodule appears months later, with nothing apparently having happened, and sometimes coinciding with a trivial viral illness.

What is done in each case

Here is the part worth knowing before asking to have something dissolved.

What it is What is called for
Early swelling Wait. It settles on its own
Accumulated or superficial product Assess; may be resolved with hyaluronidase
Non-inflammatory reaction with no infection Hyaluronidase
Inflammatory reaction Watchful waiting or a steroid
Infection Drainage, culture and an antibiotic — not hyaluronidase

That is literally what the 2024 consensus recommends, and it is the reason a lump is not dissolved by default: giving hyaluronidase on top of an infection does not solve the problem. The detail on the medicine is on its own page.

Asymmetry deserves a paragraph of its own

Because often the problem is not the filler.

No face is symmetrical. One side usually has more volume, the corner of the mouth may sit higher, one cheekbone may be more projected. That was there before the injection, and it is often noticed afterwards because the treatment has drawn attention to that area.

That said, there are asymmetries that do come from the treatment: a different amount on each side, a different plane of placement, or swelling that settles unevenly in the first few days. Telling one from the other is what is done at the appointment, by examining both sides and knowing how it looked before.

The practical rule: asymmetry is assessed once the swelling has completely settled, not before.

What is best not done

  • Massaging it yourself, unless whoever treated you has told you to.
  • Asking to have it dissolved without knowing what is there. If it is swelling, it will do nothing; if it is an infection, it may complicate matters.
  • Filling the side that looks lacking to even things up, before knowing whether there is too much on the other.
  • Judging the result in the first week.
  • Letting months go by with a lump that hurts or is red. That gets looked at.

Book an appointment

You can book your own appointment. Pick the day and time from the free slots in the diary, in a panel that opens right here, without leaving this page.

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Frequently asked questions

I can feel a small lump after the filler — is that normal?

In the first few days, some irregularity and diffuse swelling are to be expected. A firm, well-defined lump that persists after a few weeks gets assessed.

Will it go away on its own?

The swelling will. A collection of product will not: it will still be there for as long as the filler lasts, and filler lasts longer than people think.

A lump has appeared months later — why now?

It is the typical pattern of late reactions, which usually appear between three and four months. Three causes have been proposed: the product itself, an infection or biofilm, and an immune imbalance, sometimes after a viral illness.

Can they just dissolve it and be done?

It depends what it is. Only non-inflammatory reactions with no infection are treated with hyaluronidase; inflammatory ones may call for watchful waiting or a steroid, and infectious ones for drainage, culture and an antibiotic.

One side is bigger than the other — did they get it wrong?

Not necessarily. No face is symmetrical to begin with and the treatment sometimes makes visible something that was already there. It is assessed once the swelling has resolved and by examining both sides.

How long do I have to wait before deciding?

The sensible thing is to let the swelling settle completely before judging the result. If pain, redness or warmth appear, you do not wait.

Can I prevent lumps?

The amount, the plane of placement, the product chosen for that area and the technique all play a part. There is no guarantee, but not every choice carries the same risk.

And if I had it done at another clinic?

It is assessed just the same, during consulting hours. Knowing which product you were given and on what date helps a great deal.

Sources

  • Baranska-Rybak W, Lajo-Plaza JV, Walker L, Alizadeh N. Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A Consensus Recommendation on Etiology, Prevention and Management. Dermatol Ther. 2024;14(7). Late reactions usually between 3 and 4 months, occasionally from 24 hours; three aetiological hypotheses — low molecular weight product, infection or biofilm, and immune imbalance; hyaluronidase in non-inflammatory ones with no active infection, watchful waiting or a steroid in inflammatory ones, and drainage with culture and an antibiotic in infectious ones. https://pubmed.ncbi.nlm.nih.gov/38907876/
  • Murray G, Convery C, Walker L, Davies E. Guideline for the Management of Hyaluronic Acid Filler-induced Vascular Occlusion. J Clin Aesthet Dermatol. 2021. Signs that allow ischaemia to be identified and separated from other local complications. https://pubmed.ncbi.nlm.nih.gov/34188752/
  • Murray G, Convery C, Walker L, Davies E. Guideline for the Safe Use of Hyaluronidase in Aesthetic Medicine, Including Modified High-dose Protocol. J Clin Aesthet Dermatol. 2021. https://pubmed.ncbi.nlm.nih.gov/34840662/
  • Puyana C, Montes JR. Long-Term Effects of Tear Trough Hyaluronic Acid Filler: A Retrospective Study. J Clin Aesthet Dermatol. 2025. Significant improvement up to 18 months after treatment, beyond the duration usually assumed. https://pubmed.ncbi.nlm.nih.gov/41446717/
  • Khan RS, Hafeez K. Hyaluronic Acid Fillers Versus Polynucleotides for Under-Eye Rejuvenation. J Clin Med. 2026. Describes the Tyndall effect and malar oedema among the complications particular to hyaluronic acid filler in the periorbital region, an area of thin dermis and complex vascular supply. https://pubmed.ncbi.nlm.nih.gov/42452433/

Book your consultation

If you can feel a lump or see one side different from the other after a filler, what helps is not deciding on the treatment over the internet: it is having someone palpate the area and tell you what is there. At a face-to-face assessment the area is examined, we go over what product was placed and when, and we explain whether waiting, dissolving or treating something else is what is called for — including the possibility that nothing needs doing.

We also assess people who were injected somewhere else, during consulting hours.

Clinical confirmation by the surgeon

Portrait of Enrique Salmerón González

Dr Enrique Salmerón González

Specialist in Plastic, Aesthetic and Reconstructive Surgery
Registration no. 46/4624077
Portrait of Elena García Vilariño

Dr Elena García Vilariño

Specialist in Plastic, Aesthetic and Reconstructive Surgery
Registration no. 46/4624503

Last reviewed: 23 August 2026. This content is for information only and does not replace an individual assessment by a healthcare professional.

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