Description
Anti-glycation anti-wrinkle cream from SkinCeuticals. The brand’s highest concentration of Proxylane: 18%, aimed at established wrinkles and loss of firmness.
What it does
This product targets one specific pathway of ageing: glycation. Sugars bind to collagen and elastin fibres and form cross-links that make them rigid; the skin loses elasticity and radiance even without sun damage. It is the pathway that explains ageing linked to diet, metabolism and age.
18% Proxylane is the highest concentration in the range. It comes with 4.25% blueberry and pomegranate flavonoids, which reduce the oxidative stress associated with the formation of A.G.E.
3% Hepes activates the skin’s own renewal enzymes, and 1% niacinamide soothes and strengthens barrier function.
The brand reports, at 12 weeks and across five facial areas, reductions of 14% in fine lines, 11.5% in forehead wrinkles, 11% in nasolabial folds and 7% in crow’s feet and frown lines.
Who it is for
Mature skin with established wrinkles and loss of firmness and radiance. It is a treatment product, not a moisturiser: it is used on the face, neck and décolletage.
Key ingredients
- Concentrated Proxylane 18% — the highest concentration in the range; for wrinkles and laxity
- Wild berry flavonoids 4.25% — blueberry and pomegranate: reduce the oxidative stress linked to glycation
- Glycyrrhetinic acid 0.1% — soothing; works on a dull tone
- Hepes 3% — activates cell renewal enzymes and hydrates
- Niacinamide 1% — soothes and strengthens barrier function
Actives according to the manufacturer’s technical data sheet. The full ingredient list (INCI) is the one printed on the pack, and that is the one that counts: it may vary between batches and markets.
How to use it
Twice a day, a thin, even layer on the face, neck and décolletage. In the morning, after your antioxidant serum and before sunscreen. At night, after retinol if you use it.
Size
48 ml.
Not sure whether it suits you? Ask us at your next consultation: the routine is adapted to your skin, not the other way round.
A study of your skin
Study your skin with this product in it. Eight questions and a study of your skin: we cross-check what you tell us against the ingredient list of every product and against the published evidence, and send you back the routine that suits your skin and your preferences, with this product in its step. If it is not right for you, we tell you and suggest an alternative.
Validated and supervised by a team of specialists in plastic, aesthetic and reconstructive surgery.




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