Description
Hydroquinone-free depigmenting serum from ZO Skin Health. It tackles pigmentation by several routes at once—pigment production, inflammation and surface renewal—without hydroquinone and without retinol.
What it does
A dark spot is not “erased”: it fades when the circuit that produces it is interrupted. That is why the depigmenting products that work almost always combine several fronts rather than raising the dose of just one.
Tranexamic acid acts on the inflammatory pathway that activates the melanocyte, and it is currently one of the actives with the best balance of results and tolerance in melasma; unlike hydroquinone, it does not cause rebound or require breaks. Niacinamide blocks the transport of pigment that has already been made towards the surface, and it also strengthens the barrier.
Papain provides gentle enzymatic exfoliation that helps remove pigment already in the stratum corneum. It is the part you notice fastest, although the deeper work is done by the rest.
Who it is for
Pigmentation, melasma and uneven tone. As it contains no retinol, it is the option when you do not want to or cannot use one: pregnancy, breastfeeding, very reactive skin, or simply the rest days in a retinisation schedule. Without daily sunscreen it does not work: the sun reactivates pigmentation faster than any cream can fade it.
Key ingredients
- Tranexamic acid — reduces hyperpigmentation via the inflammatory pathway, without the irritation of hydroquinone
- Niacinamide (vitamin B3) — slows the transfer of melanin to the keratinocyte and strengthens barrier function
- Encapsulated peptide — targeted release to speed up the onset of the effect on skin tone
- Papain — gentle enzymatic exfoliation that removes surface pigment
- Beta-glucan and a liquorice derivative — soothe and reduce the associated redness
Details from ZO Skin Health’s Spanish portfolio. The full ingredient list (INCI) is the one printed on the pack, and that is the one that counts.
How to use it
On clean, dry skin, morning and night. During the day, always with sunscreen on top.
Size
50 ml.
Not sure whether it suits you? Ask us at your next consultation: the routine is adapted to your skin, not the other way round.
A study of your skin
Study your skin with this product in it. Eight questions and a study of your skin: we cross-check what you tell us against the ingredient list of every product and against the published evidence, and send you back the routine that suits your skin and your preferences, with this product in its step. If it is not right for you, we tell you and suggest an alternative.
Validated and supervised by a team of specialists in plastic, aesthetic and reconstructive surgery.




M.N.A. –
Buen producto, me ayuda a mantener a raya el melasma