Description
0.5% retinol with depigmenting action from ZO Skin Health. The middle step: the same system as the 0.25%, with twice the retinol.
What it does
It is the same formula as the 0.25% version with the retinol concentration doubled. The progression of this line—0.25%, 0.5%, 1%—is designed so you can step up without changing product or starting tolerance from scratch.
Retinol speeds up keratinocyte turnover, which brings pigment that has already formed to the surface and removes it, and in the medium term it stimulates collagen. The oleosomes release it gradually, which is what allows the dose to go up without irritation shooting up with it.
Bakuchiol and ascorbyl glucoside come along too: the first as a conditioning and soothing agent, the second adding the vitamin C route to skin tone.
Who it is for
Skin that has already been on 0.25% for a few weeks without problems. It is not the place to start.
Key ingredients
- Encapsulated retinol 0.5% — texture, tone and fine wrinkles, with controlled release
- Oleosome system — slow-release plant lipid vesicles
- Bakuchiol — a conditioning, soothing ingredient that improves tolerance
- Ascorbyl glucoside — a stable vitamin C derivative, working on skin tone
Details from ZO Skin Health’s Spanish portfolio. The full ingredient list (INCI) is the one printed on the pack, and that is the one that counts.
How to use it
At night, on clean, dry skin. Start twice a week and build up as tolerated. Sunscreen during the day.
Contains vitamin A (a retinoid). It is applied at night, and sun protection is essential during the day. Start twice a week and build up as your skin tolerates it. Not recommended during pregnancy or breastfeeding: ask your doctor.
Retinol and exfoliating acids, never on the same night: alternate the nights—together they do not add up, they irritate. And on an open or scabbed wound, no retinol until the skin has closed: on an open wound it delays re-epithelialisation (Hung et al., 1989).
Size
50 ml.
Not sure whether it suits you? Ask us at your next consultation: the routine is adapted to your skin, not the other way round.
A study of your skin
Study your skin with this product in it. Eight questions and a study of your skin: we cross-check what you tell us against the ingredient list of every product and against the published evidence, and send you back the routine that suits your skin and your preferences, with this product in its step. If it is not right for you, we tell you and suggest an alternative.
Validated and supervised by a team of specialists in plastic, aesthetic and reconstructive surgery.




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